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Testing Two New Therapies to Restore Sight in Advanced Retinitis Pigmentosa

Fighting Blindness Canada research

Kiora Pharmaceuticals has announced that they have dosed the first patient in a Phase 1 clinical trial for the photoswitch molecule KIO-301. This therapy is currently being tested in individuals with retinitis pigmentosa (RP). The molecule KIO-301 is designed to turn other retinal cells into light sensors and restore the ability of the eye to sense and interpret light signals. FBC supported development of related photoswitch molecules through a Restore Vision 20/20 Research Award to Dr. Richard Kramer (University of California Berkley).

In other clinical trial news, GenSight Biologics announced early results from their Phase I/II clinical trial, testing the optogenetic therapy GS030 for advanced RP. This potential treatment uses a gene therapy approach paired with special goggles. So far nine patients have received different doses of the therapy. At one year post gene therapy, the patients had no serious side effects. While the primary purpose of this trial is to test the safety of the therapy, some patients on the highest dose were able to locate and count objects, whereas before the therapy, they could barely sense light. The trial will be following patients to examine long-term safety before hopefully launching a trial to formally test if the treatment is effective.

Both treatments described above are gene-agnostic, meaning they could be effective for vision loss caused by many types of gene mutations. Current trials are only testing the therapies in patients with RP, but in the future if successful, it is hoped that these therapies could be used by individuals with other types of inherited retinal diseases.

New “WCO Alcon Dry Eye Wheel” Tool Takes Center Stage at BCLA Conference

The first in-person demonstration of the World Council of Optometry (WCO) and Alcon’s new, practical tool to help with the diagnosis and treatment of dry eye disease will happen at the upcoming 2023 BCLA Clinical Conference & Exhibition on Saturday, June 10. Global eye care practitioners (ECPs) in Manchester will hear directly from the wheel developers world-renowned educators–Professors Jennifer Craig, Lyndon Jones, and James Wolffsohn–about how and why it was designed.

The at-a-glance, interactive tool allows ECPs to easily reference three pillars of mitigation, measurement, and management through an accessible format for the broadest possible use.

Conference attendees will have the opportunity to ask questions and further explore the WCO Alcon Dry Eye Wheel, which is now available on demand along with the recent webinar series focused on the diagnosis and treatment of dry eye disease at dryeye.worldcouncilofoptometry.info. The website also features other evidence-based, practical tools that optometrists and staff can use regardless of their geographic location or available resources.

“We are excited to present the WCO Alcon Dry Eye Wheel to colleagues and friends from around the globe at BCLA,” said Lyndon Jones, DSc, FCOptom, FAAO, Director of the Centre for Ocular Research & Education (CORE) in the School of Optometry and Vision Science at the University of Waterloo (Canada). “This easy-to-use tool will help to improve quality of life for our patients as we navigate the journey toward diagnosis and treatment of dry eye disease.”

Click HERE for the full press release.

Anatomy of Eyewear: The Earth’s Bounty, an Exploration of Sustainable Eyewear

By Sarah Bureau, RO

The majority of frames available in your average dispensary will be made from one of two materials, metal or a form of plastic. Eyewear is not limited to only these choices!  

There are many natural products used in the manufacturing of eyeglasses, including horn, wood, bamboo, and even stone. In fact, the first set of sunglasses were a piece of Inuit ingenuity made by carving a slit in a piece of bone strapped over the eyes to reduce the glare of sun on snow. As we entered the Renaissance period, the need for magnifying lenses for scholars increased and eyeglasses began to be produced in a variety of materials including wood, tortoise, ivory, bone, baleen, and eventually horn. 

While the majority of modern eyewear is now manufactured from various metals and plastics, there are still many designers crafting their pieces from eco-friendly materials to this day.  Independent designers like Luke Mills from L.A.Mills Eyewear are very conscious of how eyewear production affects the environment for our generation and the next.

Natural Beauty and Functionality

Unlike the production of acetate, horn is a naturally occurring material. By taking this disregarded product from the food industry, they are able to respect the animal by creating a beautiful piece of art! Horn is a natural polymer, extremely lightweight and durable, and with the correct handling by an optician, a malleable product. When cared for properly, horn won’t deteriorate or break down like plastics. In addition, any horn material which does make it to a landfill is broken down naturally by insects and wildlife who consume it. The carbon footprint of horn is significantly smaller than plastic. Luke ensures he uses as much of the horn plate as possible, saving excess for future projects that include crafting nose pads and jewellery. Luke offers both a ready to wear and bespoke service, creating stunning and unique pieces that highlight the natural beauty of the material in distinctive shapes and individual styles.

  Many opticians have not had the opportunity to work with horn eyewear and feel nervous about handling it. I had the opportunity to sit down and chat with Luke on this topic. Here are his tips and tricks for success:

  • Hydration, hydration, hydration! Unfortunately, instructions on how and when to hydrate are not always explained clearly. Horn is a keratin, like hair, which will become brittle when dehydrated. Luke recommends using the oil or cream which accompanies the frame at least once per month. Apply generously to the entire surface of the frame and leave it to sit overnight. The next day, wipe off the excess product with a soft cloth. Sun exposure, facial creams, and the body’s natural chemistry can cause the material to dry. By following a schedule of hydration, the frame will continue to keep its lustre and strength. This is a shared responsibility between the optician to instruct and the client to comply.  Consider offering an in-house service which allows your client to drop off their frames for an extended oil bath. This level of service will set your dispensary above the rest and ensure the eyewear remains beautiful!
  • No alcohol products should be applied to horn! This is a fast way to dehydrate your specs.
  • How to spot a dehydrated horn frame? If the material looks dull or oxidized, this is a clear indication it is dry. Unless it is a matte finish, horn has a high shine when polished. The frame should be rehydrated before adjusting to avoid breakage.
  • How to adjust a horn frame? Luke recommends treating it like Optyl, allowing it to have time to heat throughout the material until it becomes pliable, testing it periodically as you heat to see if it is ready. Be careful not to overheat the frame though, as the horn can shrink and crack. Have your staff become familiar with adjustments by asking the collection for test pieces of horn.

 Another designer who is making waves with sustainability is Nina Mür Eyewear. These bespoke frames are created by hand in Spain from birch wood sourced from responsibly managed forests in Finland that hold the Forest Stewardship Council certificate. The natural properties of this material make it lightweight, highly flexible and very durable. Sustainability is the cornerstone of this collection with a focus that goes far beyond the material, including environmental impact, social and corporate responsibility.

These frames are made one-at-a-time. There is no mass production resulting in dead stock and the process supports responsible consumption. Nina Mür ensures they produce the least amount of waste possible during the production of their frames and boasts a minimal carbon footprint with a maximum level of care for the environment. If you’re wondering how interesting a frame made of wood could possibly be, just take a peek at their stunning and innovative collection which is an eye-popping gallery of art.

Check out Sarah’s March-April 2023 Optik article HERE!

Jennifer Jones Joins FBC as New President And CEO

Fighting Blindness Canada logo

Fighting Blindness Canada (FBC) announces the appointment of Jennifer Jones as the new President and Chief Executive Officer (CEO), effective May 23, 2023.

A visionary, strategic, and empathetic leader, Jennifer has devoted over 20 years to social impact, advocacy, and fundraising across the public, private, and not-for-profit sectors.

Most recently, Jennifer was the highly regarded President of the Toronto Public Library (TPL) Foundation where she helped transform the 20-year-old charity through the redevelopment of its strategic and operational plans.

“We are thrilled Jennifer is joining Fighting Blindness Canada. She will bring fresh energy, perspective, and leadership to our mission and work,” said Tara James, Board Chair. “She has a proven track record of driving sustainable growth and making a difference in the not-for-profit sector. Her timing to join the organization is perfect. Fighting Blindness Canada is about to celebrate our 50-year anniversary of funding critical vision research. After five decades of raising over $40 million towards sight-saving research, we see the positive impact that investment is having and how transformative it is to the lives of those in the vision loss community.”

FBC thanks past President and CEO, Doug Earle who left the organization in 2023 after 4 years of dedicated service. Doug led the organization through the challenging years of the COVID-19 pandemic, while advocating for improved eye health care and access to Canada’s first gene therapy for an eye disease (Luxturna™).

As President and CEO, Jennifer will be able to leverage her vision, strategic mindset, engaging leadership style, and passion for our mission – to advance vision research.

Jennifer remains the Vice Chair of PACE Independent Living Board of Directors, an organization dedicated to providing people with disabilities with the support to live with dignity and independence.

“I am thrilled to join Fighting Blindness Canada,” said Jennifer Jones. “It’s deeply rewarding to be part of an organization with a rich history of research, education, and expertise for a cause that is near and dear to my heart and to so many Canadians.”

Click HERE for the full press release.

Bash, the Shinning Elegance

Devoted to offering products that enhance the feeling of well-being, Ba&sh offers a sunwear collection which indulges femininity and elegance. The Leora model asserts its style with an oversized hexagonal acetate frame. It’s a must for strutting down the streets on sunny days!

Distributed by Lanctôt: www.rlanctot.com

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